Songi Han



(805) 893-4858
4614 PSBN
University of California, Santa Barbara
Santa Barbara, CA 93106-5080

ChemE Research Areas: 


2021 Award for Outstanding Achievements in Magnetic Resonance, Eastern Analytical Symposium
2020 W.M. Keck Foundation Award, W.M. Keck Foundation;
2020 R35 Maximizing Investigator's Research Award (MIRA), National Institutes of Health 
2019 International Society of Magnetic Resonance Fellow
2019 Biophysical Society 2019 Innovation Award
2018 Election as Fellow of the International Society of Magnetic Resonance
2015  Bessel Prize of the Alexander von Humboldt Foundation
2015  Gitte Vold Lecturer, University of California San Diego
2011  NIH Innovator Award
2010  Institute for Advanced Study Visiting Fellow of the TUM
2010  Dreyfus-Teacher Scholar Award
2008  Packard Fellowship for Science and Engineering
2007  NSF Faculty Early Career Development Award
2004  Camille and Henry Dreyfus New Faculty Award

Research Description: 

In the Han Lab, we are developing novel techniques and innovative approaches, relying on electron and nuclear spin magnetic resonance concepts that enables one to detect structure, dynamics and interaction with unprecedented sensitivity, resolution and information content. Our lab takes a two-pronged approach: (1) to develop new instrumental capabilities, methodologies and concepts, and (2) to concurrently pursue important questions in biophysics and materials science using a new combination of the just developed, as well as existing set of, technologies. An important emphasis of the development in the Han lab lies on dynamic nuclear polarization that can amplify the nuclear magnetic resonance (NMR) signal by orders of magnitudes, by transferring polarization from highly polarized electron spin probes to surrounding nuclei.

We employ strategic spin probes at molecular or material sites of interest, and pursue ambient temperature Overhauser DNP enhanced study of hydration dynamics at 10 GHz, as well as below 20 Kelvin solid state DNP enhanced NMR spectroscopy at 200 GHz. Concurrently, we also develop cw and pulsed electron spin resonance (EPR) capabilities at 200 and 240 GHz, and arbitrary waveform-powered pulsed EPR spectroscopy at X-band for enhanced studies of molecular structure and dynamics. Questions of interest include, but are not limited to, the study of lipid membrane biophysics, functional role of hydration water dynamics, membrane protein structure-dynamics-function relationship, early stages of amyloid protein aggregation, polyelectrolyte coacervation for bioinspired materials and unraveling soft matter structure-dynamics-property relationships. 


Vordiplom: Chemistry, University of Köln, Germany
Diplom: Chemistry, Aachen University of Technology
Dr. rer. nat.: Aachen University of Technology

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