Biological systems uniquely exhibit remarkable molecular recognition capabilities that exceed what can be achieved currently by rational design. Research in the Daugherty laboratory is focused on furthering our understanding of protein interactions, and using this understanding to design proteins and peptides for medical diagnostic and therapeutic applications. For example, ongoing projects involve the design of next generation targeted biological therapeutics that are both safer and more effective. They are currently applying novel biotechnologies to therapeutic challenges in cancer, cardiovascular Disease, Alzheimer’s disease, and autoimmune diseases.
The O’Malley group studies non-model microbes for biochemical production. Their approach includes isolation and deep metagenomic sequencing in order to identify novel enzymatic molecules and pathways in these organisms, and then reprogram them toward efficient biochemical conversion for applications including biofuels, commodity chemicals and therapeutics.